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Welcome!

  • Use this app to browse scRNA-seq data from embryonic UGS prostate explant cultures.
  • Genes with very low expression levels have been excluded from this app to optimise speed.
  • Raw data can be found at: GSE151944 [sample: GSM4594202]
  • Browse scRNA-seq from mouse adult prostate here!

Experimental design

To study the specification of embryonic prostate lineages, we performed scRNA-seq on UGS explant cultures collected at successive time points: E15.5 (D0), day 1 (D1), day 3 (D3), and day 6 (D6). Individually sorted populations multiplexed using MULTI-seq lipid-tagged indices in order to minimize technical confounders such as multiplets and batch effects (McGinnis et al., 2019)


Citation

Mevel R., Steiner I., Mason S., Galbraith L., Patel R., Fadlullah MZH., Ahmad I., Leung HY, Oliveira P., Blyth K., Baena E., Lacaud G., (2020)
RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development. bioRxiv 2020.06.19.161604; doi: https://doi.org/10.1101/2020.06.19.161604.

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This app was developed by Cancer Research UK Manchester Institute.

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