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To study the specification of embryonic prostate lineages, we performed scRNA-seq on UGS explant cultures collected at successive time points: E15.5 (D0), day 1 (D1), day 3 (D3), and day 6 (D6). Individually sorted populations multiplexed using MULTI-seq lipid-tagged indices in order to minimize technical confounders such as multiplets and batch effects (McGinnis et al., 2019)
Mevel R., Steiner I., Mason S., Galbraith L., Patel R., Fadlullah MZH., Ahmad I., Leung HY, Oliveira P., Blyth K., Baena E., Lacaud G., (2020)
RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development. bioRxiv 2020.06.19.161604; doi: https://doi.org/10.1101/2020.06.19.161604.
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